Social anxiety disorder-associated gut microbiota increases social fear

作者：Nathaniel L. Ritz, Marta Brocka, Mary I. Butler, C. Cowan, Camila Barrera-Bugueño, C.J.R. Turkington, L. Draper, T. Bastiaanssen, Valentine Turpin, Lorena Morales, David Campos, C. Gheorghe, A. Ratsika, V. Sharma, A. Golubeva, M. R. Aburto, A. Shkoporov, G. Moloney, Colin Hill, Gerard Clarke, David A. Slattery, T. Dinan, J. Cryan · 发表于：Proceedings of the National Academy of Sciences of the United States of America · 年份：2023 · DOI：10.1073/pnas.2308706120 · 被引用次数：62 · 研究领域：Medicine

Significance Understanding the biological basis of social anxiety disorder (SAD), one of the most disabling of the anxiety disorders, will allow for novel treatment strategies to be developed. Here, we show that gut microbiota may be such a target. Mice that received SAD patient microbiota had a specific heightened sensitivity to social fear without affecting other behaviours tested. This distinct deficit in normal social fear responses was coupled with changes in immunity and the brain.