Exercise-induced β-hydroxybutyrate contributes to cognitive improvement in aging mice

作者：Lian Wang, Liwei Mao, Danlin Zhu, Ke Li, Haoyang Gao, Muge Zhou, Jiabin Wu, Dan Yang, Ze Wang, Wenhong Wang, Yifan Guo, Yingying Xu, Peijie Chen, Weihua Xiao · 发表于：Journal of Sport and Health Science · 年份：2025 · DOI：10.1016/j.jshs.2025.101113 · 被引用次数：5 · 研究领域：Medicine

Highlights • Aerobic exercise elevated circulating β-hydroxybutyrate (β-HB) levels and improved cognitive performance in aging mice.• Loss of 3-hydroxybutyrate dehydrogenase 1 (BDH1) impaired endogenous β-HB production and attenuated exercise-induced cognitive benefits.• Exogenous β-HB mimicked exercise effects in wild-type mice but showed limited efficacy in BDH1-deficient mice.• Activation of the β-HB/G protein-coupled receptor 109A–peroxisome proliferator-activated receptor gamma (GPR109A–PPARγ) axis promoted antioxidant and anti-inflammatory responses that support cognitive function in aging.