Revolutionizing Drug Development: Harnessing the Potential of Organ-on-Chip Technology for Disease Modeling and Drug Discovery

作者：Jehan Zeb · 发表于：Pakistan BioMedical Journal · 年份：2025 · DOI：10.54393/pbmj.v8i1.1216 · 被引用次数：1

One of the groundbreaking advancements in the field of biomedical research is the development of organoids or organ on chip technology. Promising potential of this technology has reshaped the future of disease modelling and drug discovery. Organoids are microfluidic devices which can mimic the physiological functions of natural organs of human body. Animal models are being used in laboratories to evaluate the drug effectiveness but due to the recent ethical concerns, regarding the use of animals, are affecting drug development and treatment for various diseases. But organ on chip is an emerging tool which is filling the gap between animal models and outcomes of drug treatment by eliminating the ethical concerns. Demand for precision medicine is growing due to rapid arousal of various deadly disease but traditional methods of developing drugs fall short as they can’t exactly replicate the human physiology. So instead of using animal models or cell cultures to design drug, to detect the its efficacy and toxicity, organ on chip technology is perceived to be a best option. It saves the time and resources that were being wasted, due the use of animal models, during the preclinical and clinical trials of the drug.  On the other hand, organoids are more reliable in satisfying the demand of precision medicine.   These artificial organs provide a bioengineered platforms mimicking the specific functions of living organs such as gut peristalsis and lung breathing in a very controlled m...