Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as predictors of tumor response in hepatocellular carcinoma after DEB-TACE

作者：I. Schobert, L. Savic, J. Chapiro, Khaled Bousabarah, E. Chen, F. Laage-gaupp, Jonathan Tefera, N. Nezami, Mingde Lin, J. Pollak, T. Schlachter · 发表于：European Radiology · 年份：2020 · DOI：10.1007/s00330-020-06931-5 · 被引用次数：108 · 研究领域：Medicine

Objectives To investigate the predictive value of quantifiable imaging and inflammatory biomarkers in patients with hepatocellular carcinoma (HCC) for the clinical outcome after drug-eluting bead transarterial chemoembolization (DEB-TACE) measured as volumetric tumor response and progression-free survival (PFS). Methods This retrospective study included 46 patients with treatment-naïve HCC who received DEB-TACE. Laboratory work-up prior to treatment included complete and differential blood count, liver function, and alpha-fetoprotein levels. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were correlated with radiomic features extracted from pretreatment contrast-enhanced magnetic resonance imaging (MRI) and with tumor response according to quantitative European Association for the Study of the Liver (qEASL) criteria and progression-free survival (PFS) after DEB-TACE. Radiomic features included single nodular tumor growth measured as sphericity, dynamic contrast uptake behavior, arterial hyperenhancement, and homogeneity of contrast uptake. Statistics included univariate and multivariate linear regression, Cox regression, and Kaplan–Meier analysis. Results Accounting for laboratory and clinical parameters, high baseline NLR and PLR were predictive of poorer tumor response ( p  = 0.014 and p  = 0.004) and shorter PFS ( p  = 0.002 and p  < 0.001). When compared to baseline imaging, high NLR and PLR correlated with non-spherical tumor growth ( p  = 0....