High-altitude erythrocytosis: mechanisms of adaptive and mal-adaptive responses.

作者：F. Villafuerte, T. Simonson, Daniela Bermudez, F. Lèon-Velarde · 发表于：Physiology · 年份：2022 · DOI：10.1152/physiol.00029.2021 · 被引用次数：79 · 研究领域：Medicine

Erythrocytosis, or increased production of red blood cells, is one of the most well-documented physiological traits that varies within and among in high-altitude populations. Although a modest increase in blood O2-carrying capacity may be beneficial for life in highland environments, erythrocytosis can also become excessive and lead to maladaptive syndromes such as Chronic Mountain Sickness (CMS).