Emerging Approaches to DNA Data Storage: Challenges and Prospects

作者：Andrea Doricchi, Casey M. Platnich, Andreas L. Gimpel, F. Horn, Max Earle, Germán Lanzavecchia, A. Cortajarena, L. Liz‐Marzán, Na Liu, Reinhard Heckel, R. Grass, R. Krahne, U. Keyser, D. Garoli · 发表于：ACS Nano · 年份：2022 · DOI：10.1021/acsnano.2c06748 · 被引用次数：205 · 研究领域：Medicine

With the total amount of worldwide data skyrocketing, the global data storage demand is predicted to grow to 1.75 × 1014 GB by 2025. Traditional storage methods have difficulties keeping pace given that current storage media have a maximum density of 103 GB/mm3. As such, data production will far exceed the capacity of currently available storage methods. The costs of maintaining and transferring data, as well as the limited lifespans and significant data losses associated with current technologies also demand advanced solutions for information storage. Nature offers a powerful alternative through the storage of information that defines living organisms in unique orders of four bases (A, T, C, G) located in molecules called deoxyribonucleic acid (DNA). DNA molecules as information carriers have many advantages over traditional storage media. Their high storage density, potentially low maintenance cost, ease of synthesis, and chemical modification make them an ideal alternative for information storage. To this end, rapid progress has been made over the past decade by exploiting user-defined DNA materials to encode information. In this review, we discuss the most recent advances of DNA-based data storage with a major focus on the challenges that remain in this promising field, including the current intrinsic low speed in data writing and reading and the high cost per byte stored. Alternatively, data storage relying on DNA nanostructures (as opposed to DNA sequence) as well as on...