Hazards of diethyl phthalate (DEP) exposure: A systematic review of animal toxicology studies

作者：J. Weaver, Brandiese E. J. Beverly, N. Keshava, A. Mudipalli, Xabier Arzuaga, C. Cai, A. Hotchkiss, S. Makris, Erin E. Yost · 发表于：Environment International · 年份：2020 · DOI：10.1016/j.envint.2020.105848 · 被引用次数：105 · 研究领域：Medicine

Background: Diethyl phthalate (DEP) is widely used in many commercially available products including plastics and personal care products. DEP has generally not been found to share the antiandrogenic mode of action that is common among other types of phthalates, but there is emerging evidence that DEP may be associated with other types of health effects. Objective: To inform chemical risk assessment, we performed a systematic review to identify and characterize outcomes within six broad hazard categories (male reproductive, female reproductive, developmental, liver, kidney, and cancer) following exposure of nonhuman mammalian animals to DEP or its primary metabolite, monoethyl phthalate (MEP). Methods: A literature search was conducted in online scientific databases (PubMed, Web of Science, Toxline, Toxcenter) and Toxic Substances Control Act Submissions, augmented by review of online regulatory sources as well as forward and backward searches. Studies were selected for inclusion using PECO (Population, Exposure, Comparator, Outcome) criteria. Studies were evaluated using criteria defined a priori for reporting quality, risk of bias, and sensitivity using a domain-based approach. Evidence was synthesized by outcome and life stage of exposure, and strength of evidence was summarized into categories of robust, moderate, slight, indeterminate, or compelling evidence of no effect, using a structured framework. Results: Thirty-four experimental studies in animals were included in t...