2024 Update of the RECOVER-Adult Long COVID Research Index.

作者：L. Geng, K. Erlandson, Mady Hornig, Rebecca Letts, Caitlin A. Selvaggi, H. Ashktorab, Ornina Atieh, Logan Bartram, H. Brim, Shari Brosnahan, Jeanette P. Brown, Mario Castro, A. Charney, Peter Chen, S. Deeks, Nathaniel B. Erdmann, V. Flaherman, Maher A Ghamloush, Paul Goepfert, Jason D. Goldman, Jenny E. Han, Rachel Hess, E. Hirshberg, Susan E. Hoover, S. Katz, J. Kelly, Jonathan D. Klein, Jerry A. Krishnan, J. Lee-Iannotti, Emily B. Levitan, Vince C Marconi, Torri D. Metz, Matthew E. Modes, Janko Ž. Nikolich, Richard M. Novak, I. Ofotokun, Megumi Okumura, Sairam Parthasarathy, Thomas F. Patterson, M. Peluso, Athena Poppas, Orlando Quintero Cardona, Jake Scott, J. Shellito, Z. Sherif, Nora G. Singer, Barbara S. Taylor, Tanayott Thaweethai, Monica Verduzco-Gutierrez, Juan P. Wisnivesky, Grace A. McComsey, Leora I. Horwitz, Andrea S. Foulkes, Sushma K. Cribbs, Anyssa G. Francis, Tina P. Hang, Ketteria D. Ingram, Jordi Lainez, Zanthia Wiley, Kennedy C. Lewis, Arijan Ager, Mary M. Atha, R. Fineman, Natalie Gray, Ash Grimes, Lauren N. Hewitt, Christopher Huerta, Brandi Johnson, L. Khalil, D. Kleinhenz, Alexandra Koumanelis, Matthew A. Lee, Matthew B. Litvack, Bernadine Panganiban, K. Rahman, V. E. Smith, A. Stringer, Maliya Tolbert, J. Traenkner, Kristen Unterberger, Erika Wimberly, Jenny E. Han, Vince C Marconi, I. Ofotokun, Rachel E. Patzer, Tiffany A. Walker, Rachael Abraham, Franchesca A. Aguilar, Ghazal Ahmadi-Izad, Dilshad R. Ahmed, Alicarmen Alvarez, Blake Anderson, Walter D. Asencios, Casey L. Beaty, B. Bedi, Jasmine A. Berry, Donchel Boone, M. Bower, J. Bremner, Corbin Brent, Ke'Ara Brown-Smith, Rachel Bull, Gustavo Capo, Kelechi Carl-Igwe, Calista Chitadze, Nachi Chukwumerije, Erna Clyburn, Shelby Collins, Julie Costello, Grace Couture, Angel Craft, Xiangqin Cui, C. del Rio, Joshua F. Detelich, Cartia Dixon, Jeanne Dow, D'Andrea Doyle, Jannah Elchommali, Imani Elsey, Nicole Franks, Julia W. Gallini, Evan Gutter, Jess Harding, Liliana Hernandez, Carla Holloway, Cynthia Ifejika, Rijalda Jasarevic, V. Javia, Mykayla Jeter, Yasha Joseph, Monica Juarez, Caitlin M. Kirkpatrick, Athena Koumanelis, Rebecca Kozoman, Shilpa Krishnan, Jose D. Leon, V. Lew, Cheryl L. Maier, Nour Makkaoui, Mara Maroney, Christopher F. Martin, L. Mbogo, Atuarra McCaslin, Jerrod McIntyre, Abeer Moanna, Miranda Montoya, Elena Morales, Caitlin A. Moran, Calista E. Murray, Roslin Nelson, Tran Nguyen, B. Ojoawo, Eileen Osinski, Sofia Oviedo, Yolanda Paredes-Gaitan, M. Prude, Grace Ramakrishnan, P. Rebolledo, M. Roberts, Keysha Robinson, Chantrice Rogers, Nadine Rouphael, Charles Searles, Marni Segall, Anand Shah, Ruvina Silva, Cheryl Simpson, Krystal Simpson-Derrell, Talib Sirajud-Deen, Jacob Stroud, M. Suthar, C. Sylber, A. Sylvera, Larissa J. Teunis, Kodasha M. Thomas, K. Titanji, Christopher Toy, Alex D. Truong, V. Vaccarino, Kris Varney, Kartavya Vyas, Kurt Vyas, Max Walkow, Tamara Wesley, Juton R. Winston, Terra J. Winter, C. Wongtrakool, Jennifer C. Gander, Robert B. Neuman, Patricia A. Bush, A. F. Hudgins, Imanii Kolailat, Mónica Martínez, Sierra G. Thompson, Priscilla Pemu, Annette Dandy, C. Ibeawuchi, B. Lawrence, Jan Morgan‐Billingslea, Elizabeth I. Ojemakinde, J. Mullington, Ai-ris Collier, Tamara Fong, Monika Haack, Kristine S P Hauser, Jason H. Maley, Y. Quintana, Lynn Shaughnessy, Kathryn Stephenson, Robert J. Thomas, Robert Torres, Jai G Marathe, Elizabeth R Duffy, Naomi Hamburg, Misaki . Kobayashi, George T. O'Connor, Fitzgerald Shepherd, Charles T. Williams, Hai-hua Zhang, Bruce D. Levy, Masanori Aikawa, L. Baden, Gaston Baslet, Lindsey Bennett, Shamik Bhattacharyya, Julie E. Buring, R. E. Cagnina, Li Qing Chen, Cheryl R. Clark, P. Cohen, C. Czeisler, Peter Estill, Elizabeth Gay, Jessica M Hong, Daniela Lamas, Nomi C. Levy-Carrick, JoAnn Manson, Tobasom Monafrared, S. Redline, Elijah J. Remis, Daniel Schilkrut, H. Sesso, S. Solomon, Jeffrey A. Sparks, Lia Spencer, D. Systrom, Phyo Thu, D. Walt, George Washko, M. Whittelsey, Rebecca Wiener, J. John, Amberly Ticotsky, Ingrid V. Bassett, G. Alba, Taing N Aung, L. C. Ginns, Jennifer Haas, Yan-Xin Hu, B. Juelg, Diane G. Kanjilal, Arthur Y. Kim, E. Klerman, Gregory Lewis, Bisola O. Ojikutu, Roy H Perlis, J. Rosand, Z. Wallace, Dean Xerras, D. Zionts, Honorine D. Ward, Deborah Blazey-Martin, Maher A Ghamloush, Michael Jordan, L. Kogelman, T. Carton, L. Miele, T. Brown, Erica A. Sutherland, J. Fuloria, Paula Datri, Michael Hagensee, Cathryn Leggio, Allen Perkins, Amber J Trauth, S. Trotter, Alexander Van Deerlin, Sharon Weiser, Madeline Young, Nathaniel B. Erdmann, Emily B. Levitan, A. Tita, D. Armstrong, Susan E. Binkley, Kenneth Blackwell, Annalia Causey, Felice Cook, J. Domingo, Conner Donahue, Maitlyn Eady, Jeffrey Edberg, Noah Garcia-McClaney, Melissa Garner, Brandon Gray, Wanda Hall, Cady Hart, Camden L Hebson, Bertha Hidalgo, Kaylen Holtzapfel, Alexis Jinright, Suzanne E. Judd, Teri Kennedy, Leigh Kirkwood, Megan Maier, Patricia McCormack, Kevin Mitchell, Aoyjai P. Montgomery, Myriam Peralta-Carcelen, Juan P. Pilco, Leigh Powell, Rachael Shevin, Sidney Skipworth, L. Spurgeon, Gregory Ware, Rosanne Wilson, Dana Woodruff, B. Young, Mark Gillespie, Casey L. Daniel, Jamie Hansel, Jing Wu, H. Ashktorab, H. Brim, A. Laiyemo, Z. Sherif, Saima Durrani, Ali Nezamloo, Julius S. Ngwa, Noelle Njoku, Monique P. Gentil, A. Mehari, Akbar Solemani, Linda Chang, Paul Thuluvath, Mhret Alemu, Jordan Anderson, Mahak Chauhan, Sung Cho, Karli Goodman, Gandi Lanke, Ralph Lebron, Anurag Maheshwari, Jina Ok, Chau To, J. Shellito, Frank L. Greenway, John P. Kirwan, Clifford J. Rosen, Abigail Arruda, Ivette F. Emery, Theresa Roelke, Paul Berger, Susan E. Hoover, Lora Black, Brian Tjarks, Vivian Fonseca, Shaveeta Gupta, Michele T. Longo, Mei Yang, Cecilia M. Shikuma, Dominic C Chow, Louis MarGangcuangco, Mario Castro, Charles Bengtson, Theresa Howard, Brandon Koontz, L. A. Spikes, Christopher Simmons, S. Whiteheart, Beth A. Garvy, J. Wood, Gailen D. Marshall, Vishnu Garla, Joy Kuebler, Utsav Nandi, Andrew Vasey, David E. Warren, John D. Dickinson, T. VanWagoner, A. Bogie, Judith A. James, J. Scott, Fatima I. Sukhera, Carlos A. Luciano Roman, Sigrid Perez Frontera, Jorge Santana Bagur, S. Hodder, J. Bardes, Daphne Dominique-Villanueva, Joy J Juskowich, Rebecca Reece, Arif Sarwari, Marta Certa, Erica Chessier, Emily Everett, Elijah Kindred, Pastor C. Harris, Praveen Sudhindra, Lela Olds, Lisa Aponte‐Soto, Marina Del Rios, Maya Z. Diaz, Alejandra L. Ibañez, Cesar Rolon, Savannah Cranford, Daniel Brown, Jennifer Dixon, Lisa Gale, Savannah Hammerl, Kimberly Hartwig, A. Madineni, Peyton Swearingen, Monica Hendrickson, Seth Noland, Tracy Terlinde, Brianna Hobbs, Jonathan D. Klein, Jerry A. Krishnan, Janet Y Lin, Naoko Muramatsu, Bellur Prabhakar, Heather M. Prendergast, T. V. Vanden Hoek, Dara R Adams, Aileen Baker, Sunni Barbera, Sanjib Basu, Susan Bleasdale, Andrew D. Boyd, Taylor Breiter, Irina A. Buhimschi, M. Carrithers, Rashmika Chalamalla, David Chestek, Judith A. Cook, Dawood Darbar, R. Dasgupta, Felicia Davis Blakley, J. Delisa, Kathleen R. Diviak, Meghan F. Donlon, Mark S Dworkin, Angela Ellison, Clarie Flanigan, Michael B. Freedman, Lynn B. Gerald, Wayne H. Giles, H. S. Gordon, Bayan Hammad, Sharon Hasek, Wendy Hasse, Martyna Hryniewicka, S. Illendula, Nahed Ismail, Akash Jain, Kyle J. Jennette, Grace Kadubek, D. Kent, D. Kent, Keri S. Kim, P. Kotini-Shah, Lucia Large, James . Lash, Jun Lu, Abeer M. Mahamed, S. Malchenko, Miriam Martínez, C. Mauntel‐Medici, Mark McCauley, Martha G. Menchaca, Robin Mermelstein, David J. Moreno, Liam Morrissy, Hugh Musick, Lourdes Norwick, Richard M. Novak, Marilyn Ortiz, Khushboo Patel, Nicolas L. Perez, Neil H. Pliskin, Sam Pope, Bharati Prasad, Barbara Predki, J. Quigley, Ramaswamy Ramchandran, Ana Ramirez, Sarah Rappe, Jalees Rehman, Matthew Rowley, G. Rudraraju · 发表于：Journal of the American Medical Association (JAMA) · 年份：2024 · DOI：10.1001/jama.2024.24184 · 被引用次数：72 · 研究领域：Medicine

Importance Classification of persons with long COVID (LC) or post-COVID-19 condition must encompass the complexity and heterogeneity of the condition. Iterative refinement of the classification index for research is needed to incorporate newly available data as the field rapidly evolves. Objective To update the 2023 research index for adults with LC using additional participant data from the Researching COVID to Enhance Recovery (RECOVER-Adult) study and an expanded symptom list based on input from patient communities. Design, Setting, and Participants Prospective, observational cohort study including adults 18 years or older with or without known prior SARS-CoV-2 infection who were enrolled at 83 sites in the US and Puerto Rico. Included participants had at least 1 study visit taking place 4.5 months after first SARS-CoV-2 infection or later, and not within 30 days of a reinfection. The study visits took place between October 2021 and March 2024. Exposure SARS-CoV-2 infection. Main Outcomes and Measures Presence of LC and participant-reported symptoms. Results A total of 13 647 participants (11 743 with known SARS-CoV-2 infection and 1904 without known prior SARS-CoV-2 infection; median age, 45 years [IQR, 34-69 years]; and 73% were female) were included. Using the least absolute shrinkage and selection operator analysis regression approach from the 2023 model, symptoms contributing to the updated 2024 index included postexertional malaise, fatigue, brain fog, dizz...