Antimicrobial lanostane triterpenoids from the fruiting bodies of Ganoderma applanatum

作者：Jing Shi, Guoping Chen, Qian Sun, Shishuai Meng, Wei-Qun Chi · 发表于：Journal of Asian natural products research · 年份：2021 · DOI：10.1080/10286020.2021.2017899 · 被引用次数：6 · 研究领域：Medicine

Abstract A chemical investigation on the 90% EtOH extract of the fruiting bodies of Ganoderma applanatum led to the isolation of three new lanostane triterpenoids, designated as 25-methoxy-11-oxo-ganoderiol D (1), 3-oxo-25-methoxy-24,26-dihydroxy-lanosta-7,9(11)-diene (2), and 3β-acetyloxy-lucidone H (3). Structural elucidation of all the compounds were performed by spectral methods such as 1 D and 2 D (1H- 1H COSY, HMQC, and HMBC) NMR spectroscopy. All the triterpenoids were in vitro evaluated for their antimicrobial activities against six pathogenic microorganisms. Compounds 1 and 2 exhibited some activities against three Gram positive bacteria with MIC values less than 60 μg/ml. Graphical Abstract