Executive Summary of the Second International Guidelines for the Diagnosis and Management of Pediatric Acute Respiratory Distress Syndrome (PALICC-2)

作者：G. Emeriaud, Yolanda M. López-Fernández, N. Iyer, M. Bembea, A. Agulnik, R. Barbaro, F. Baudin, A. Bhalla, Werther Brunow de Carvalho, C. Carroll, I. Cheifetz, M. Chisti, P. Cruces, M. Curley, M. Dahmer, H. Dalton, S. Erickson, S. Essouri, Analía Fernández, H. Flori, Jocelyn R. Grunwell, P. Jouvet, E. Killien, M. Kneyber, S. Kudchadkar, S. K. Korang, J. Lee, D. Macrae, A. Maddux, V. Modesto i Alapont, B. Morrow, V. Nadkarni, N. Napolitano, C. Newth, M. Pons-Òdena, M. Quasney, P. Rajapreyar, J. Rambaud, A. Randolph, P. Rimensberger, C. Rowan, L. N. Sanchez-Pinto, A. Sapru, M. Sauthier, S. Shein, Lincoln S Smith, K. Steffen, M. Takeuchi, Neal J. Thomas, S. Tse, Stacey L. Valentine, Shan L. Ward, R. Watson, N. Yehya, J. Zimmerman, R. Khemani · 发表于：Pediatric Critical Care Medicine · 年份：2023 · DOI：10.1097/pcc.0000000000003147 · 被引用次数：251 · 研究领域：Medicine

OBJECTIVES: We sought to update our 2015 work in the Second Pediatric Acute Lung Injury Consensus Conference (PALICC-2) guidelines for the diagnosis and management of pediatric acute respiratory distress syndrome (PARDS), considering new evidence and topic areas that were not previously addressed. DESIGN: International consensus conference series involving 52 multidisciplinary international content experts in PARDS and four methodology experts from 15 countries, using consensus conference methodology, and implementation science. SETTING: Not applicable. PATIENTS: Patients with or at risk for PARDS. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Eleven subgroups conducted systematic or scoping reviews addressing 11 topic areas: 1) definition, incidence, and epidemiology; 2) pathobiology, severity, and risk stratification; 3) ventilatory support; 4) pulmonary-specific ancillary treatment; 5) nonpulmonary treatment; 6) monitoring; 7) noninvasive respiratory support; 8) extracorporeal support; 9) morbidity and long-term outcomes; 10) clinical informatics and data science; and 11) resource-limited settings. The search included MEDLINE, EMBASE, and CINAHL Complete (EBSCOhost) and was updated in March 2022. Grading of Recommendations, Assessment, Development, and Evaluation methodology was used to summarize evidence and develop the recommendations, which were discussed and voted on by all PALICC-2 experts. There were 146 recommendations and statements, including: 34 recommendat...