Resveratrol-embedded hollow cerium oxide nanomedicine targeted treat inflammatory bowel disease through ROS clearance, intestinal mucosal immune homeostasis recovery and gut microbiota modulation

作者：Tianlin Wang, Xiaoxia Lin, Wenjie Li, Xing Li, Xiaodong Lin, Ning Li, Yan Ma, Lianjun Song, Xianqing Huang, Tiange Li · 发表于：Materials Today Bio · 年份：2026 · DOI：10.1016/j.mtbio.2026.102765 · 被引用次数：8 · 研究领域：Medicine

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract that is difficult to cure. The crucial pathogenic factors of IBD are mainly caused by the overexpression of pro-inflammatory cytokines and the disturbance of gut microbiota triggered by excessive reactive oxygen species (ROS). Herein, the resveratrol-embedded hollow cerium oxide composite nanomaterials with surface modified hyaluronic acid (Res-CeO2@HA) is developed to restore intestinal mucosal immune homeostasis and modulate gut microbiota via effective elimination of ROS-inflammation. The synthetic nanomedicine integrates the enzyme-like activity of CeO2, the antioxidant properties of Res, and the targeting capabilities of HA. Results showed that Res-CeO2@HA had significant advantages in ROS clearance and colon targeting. And it balanced the expression of inflammatory cytokines by inhibiting M1 macrophage polarization, promoting M2 macrophage polarization, and modulating the TLR4/NF-κB signaling pathway to alleviate IBD in mice. Furthermore, it is found that Res-CeO2@HA significantly improved the homeostasis of the intestinal microbiota. This friendly and multifunctional nanomedicine may provide new strategies for the clinical treatment of IBD.