Four Core Genotypes mice harbour a 3.2MB X-Y translocation that perturbs Tlr7 dosage

作者：Jasper Panten, S. D. Prete, James P. Cleland, Lauren M. Saunders, J. van Riet, Anja Schneider, P. Ginno, Nina Schneider, Marie-Luise Koch, M. Gerstung, O. Stegle, J. Turner, Edith Heard, D. T. Odom · 发表于：bioRxiv · 年份：2024 · DOI：10.1038/s41467-024-52640-8 · 被引用次数：35 · 研究领域：Medicine、Biology

The Four Core Genotypes (FCG) is a mouse model system heavily used to disentangle the function of sex chromosomes and hormones. We report that a copy of a 3.2 MB region of the X chromosome has translocated to the YSry- chromosome and thus increased the expression of multiple genes including the auto-immune master regulator Tlr7. This previously-unreported X-Y translocation complicates the interpretation of studies reliant on FCG mice.