Cerenkov Luminescence Tomography for In Vivo Radiopharmaceutical Imaging

作者：Jianghong Zhong, Chenghu Qin, Xin Yang, Shu-Ping Zhu, Xing Zhang, Jie Tian · 发表于：International Journal of Biomedical Imaging · 年份：2011 · DOI：10.1155/2011/641618 · 被引用次数：49 · 研究领域：Materials Science、Medicine、Computer Science

Cerenkov luminescence imaging (CLI) is a cost-effective molecular imaging tool for biomedical applications of radiotracers. The introduction of Cerenkov luminescence tomography (CLT) relative to planar CLI can be compared to the development of X-ray CT based on radiography. With CLT, quantitative and localized analysis of a radiopharmaceutical distribution becomes feasible. In this contribution, a feasibility study of in vivo radiopharmaceutical imaging in heterogeneous medium is presented. Coupled with a multimodal in vivo imaging system, this CLT reconstruction method allows precise anatomical registration of the positron probe in heterogeneous tissues and facilitates the more widespread application of radiotracers. Source distribution inside the small animal is obtained from CLT reconstruction. The experimental results demonstrated that CLT can be employed as an available in vivo tomographic imaging of charged particle emitters in a heterogeneous medium.