Mechanisms of abdominal aortic aneurysm progression: A review

作者：Jianghui Gao, Wei Guo · 发表于：Vascular Medicine · 年份：2021 · DOI：10.1177/1358863x211021170 · 被引用次数：38 · 研究领域：Medicine

Abdominal aortic aneurysm (AAA) is a common disease associated with significant cardiovascular morbidity and mortality. Up to now, there is still controversy on the choice of treatment method of AAA. Even so, the mechanisms of AAA progression are poorly defined, making targeting new therapies problematic. Current evidence favors an interaction of the hemodynamic microenvironment with local and systemic immune responses. In this review, we aim to provide an update of mechanisms in AAA progression, involving hemodynamics, perivascular adipose tissue, adventitial fibroblasts, vasa vasorum remodeling, intraluminal thrombus, and distribution of macrophage subtypes.