Hypersomatotropism in 3 Cats without Concurrent Diabetes Mellitus

作者：Jon M Fletcher, Christopher J Scudder, Matti Kiupel, H. Pipe-Martin, Patrick J. Kenny, P. Mantis, Joe Fenn, K. Smith, R. V. Blair, L. Granger, S. Niessen · 发表于：Journal of Veterinary Internal Medicine · 年份：2016 · DOI：10.1111/jvim.14360 · 被引用次数：24 · 研究领域：Medicine

A 16-year-old, 6.8 kg, castrated male Domestic Short-haired cat was presented to Louisiana State University Veterinary Teaching Hospital with a 3-day history of progressive ataxia, tetraparesis, and altered mentation. The owner did not report having observed evidence of polyuria or polydipsia. The cat had been diagnosed with hypertrophic cardiomyopathy (HCM) 4 years earlier and was receiving atenolol, benazepril, and aspirin. Dull mentation, patchy truncal alopecia, and a grade III of VI systolic heart murmur were noted during the physical examination. The neurologic examination revealed ambulatory tetraparesis that was more severe in the pelvic limbs, plantigrade stance, proprioceptive deficits in all limbs, and positional vertical nystagmus. The CBC, biochemistry profile, and abdominal ultrasound were unremarkable. The blood glucose concentration measured with the chemistry analyzer was 130 mg/dL (7.2 mmol/L). Subsequent blood glucose measurements (n = 6) using a glucometer validated for use in cats ranged from 122 mg/dL (6.7 mmol/L) to 159 mg/dL (8.7 mmol/L) during the 5-day period the cat was hospitalized. These blood glucose concentrations combined with a normal serum fructosamine concentration (228 lmol/L, RI 192–288) ruled out overt diabetes mellitus (DM). Two-dimensional echocardiogram revealed severe asymmetric septal hypertrophy (8.7 mm in diastole). The left atrium was normal in size and all valves appeared normal. Continuous wave Doppler through the left ventricul...