Mental Disorders and Weight Change in a Prospective Study of Bariatric Surgery Patients: 7 Years of Follow-up

作者：M. Kalarchian, Wendy C. King, M. Devlin, Amanda S. Hinerman, M. Marcus, S. Yanovski, J. Mitchell · 发表于：Surgery for Obesity and Related Diseases · 年份：2019 · DOI：10.1016/j.soard.2019.01.008 · 被引用次数：75 · 研究领域：Medicine

Background: Long-term, longitudinal data are limited on mental disorders after bariatric surgery. Objective: To report mental disorders through 7 years post-surgery and examine their relationship with changes in weight and health-related quality of life (HRQoL). Setting: Three U.S. academic medical centers. Method: As a sub-study of the Longitudinal Assessment of Bariatric Surgery Consortium, 199 adults completed the Structured Clinical Interview for DSM-IV prior to Roux-en-Y Gastric Bypass (RYGB) or Laparoscopic Adjustable Gastric Band (LAGB). Participants who completed ≥1 follow-up through 7-years post-surgery are included (n=173; 86.9%). Mixed models were used to examine mental disorders over time, and among the RYGB subgroup (n=104), their relationship with long-term (≥4 years) pre- to post-surgery changes in weight and HRQoL, measured with the Short Form-36 Health Survey, and with weight regain from nadir. Results: Compared with pre-surgery (34.7%), the prevalence of having any mental disorder was significantly lower 4 years (21.3%; p<.01) and 5 years (19.2%; p=.01), but not 7 years (29.1%; p=.27) following RYGB. The most common disorders were not related to long-term weight loss post-RYGB. However, independent of weight change, mood and anxiety disorders, both pre- and post-surgery, were significantly related to less improvement in mental (but not physical) HRQoL. Having a concurrent mood disorder appeared to be associated with greater weight regain (6.4% of maximum wei...