The SAM-Krom biomonitoring study shows occupational exposure to hexavalent chromium and increased genotoxicity in Denmark.

作者：A. Saber, M. Levin, Pete Kines, K. Aimonen, Lucas Givelet, Christina Andersen, A. Huusom, Tanja Carøe, N. Ebbehøj, F M Christensen, Zheshun Jiang, Thomas Lundh, Håkan Tinnerberg, M. Albin, M. Engfeldt, K. Broberg, J. Catalán, Katrin Loeschner, Karsten Fuglsang, U. Vogel · 发表于：International Journal of Hygiene and Environmental Health · 年份：2024 · DOI：10.1016/j.ijheh.2024.114444 · 被引用次数：8 · 研究领域：Medicine

BACKGROUND Hexavalent chromium (Cr(VI)) is a carcinogen. Exposure to Cr(VI) may occur in different industrial processes such as chrome plating and stainless steel welding. The aim of this study was to assess occupational exposure to Cr(VI) in Denmark. METHODS This cross-sectional study included 28 workers and 8 apprentices with potential Cr(VI) exposure and 24 within company controls, all recruited from six companies and one vocational school. Use of occupational safety and health (OSH) risk prevention measures were assessed through triangulation of interviews, a questionnaire and systematic observations. Inhalable Cr(VI) and Cr-total were assessed by personal air exposure measurements on Cr(VI) exposed participants and stationary measurements. Cr concentrations were measured in urine and in red blood cells (RBC) (the latter reflecting Cr(VI)). Genotoxicity was assessed by measurement of micronuclei in peripheral blood reticulocytes (MNRET). RESULTS At announced visits, a consistent high degree of compliance to OSH risk prevention measures were seen in 'chromium bath plating' for both technical devices (e.g. ventilation, plastic balls, sheet coverings) and in the use of personal protective equipment (e.g. gloves, respirators), yet a lesser degree of compliance was observed in 'stainless steel welding'. The geometric mean of the air concentration of Cr(VI) was 0.26 μg/m3 (95% confidence interval (CI): 0.12-0.57) for the Cr(VI)-exposed workers and 3.69 μg/m3 (95% CI: 1.47-9...