P0222 Determinants of Sarcopenia in Crohn’s Disease: Effects of Short Bowel Syndrome and Protein Intake

作者：G. Becherucci, A. Del Gaudio, J. Iaccarino, E. Foscarini, F. Profeta, B. Rondinone, S. Distante, V. Petito, L. Masi, S. Troisi, C. Pane, F. di Vincenzo, C. Covello, V. Calvez, L. Laterza, C. Marmo, I. Mignini, M. Pizzoferrato, S. Ennas, G. Cammarota, M. C. Mentella, L. Lopetuso, A. Gasbarrini, A. Papa, F. Scaldaferri · 发表于：Journal of Crohn's & Colitis · 年份：2026 · DOI：10.1093/ecco-jcc/jjaf231.403

Crohn’s disease (CD) is a leading cause of Short Bowel Syndrome (SBS) in adults, which may progress to intestinal failure (IF) when intravenous nutritional or electrolyte supplementation is required. Patients with CD are at increased risk of malnutrition, sarcopenia, and altered eating habits. Early identification of risk and protective factors is crucial to optimize nutritional management, guide therapy, and improve clinical outcomes. We conducted a cross-sectional study including CD outpatients. Clinical characteristics, surgical history, anthropometric measurements (including bioimpedance analysis [BIA] and hand grip strength), and dietary habits were assessed. Statistical significance was set at p < 0.05. A total of 232 CD patients were included (47.4% female; mean age 49.8 ± 13.6 years). According to the Montreal Classification, 47.0% were B2 and 27.2% B3. Overall, 67.7% had undergone bowel resections, and 11.2% had SBS or ≥ 3 bowel resections. Nearly half (49.6%) had received two or more advanced therapies. Anthropometric measures were: BMI 24.1 ± 4.8 kg/m², fat-free mass 77.1 ± 11.6 %, fat mass 22.7 ± 11.0 %, appendicular skeletal muscle mass (ASMM) 16.5 ± 4.5 kg, phase angle 6.17 ± 1.08°, and hand grip strength 28.0 ± 18.7 kg. High protein intake was protective against sarcopenia (OR 0.25; 95% CI 0.08–0.73; p = 0.012), while older age (OR 1.03; 95% CI 1.00–1.07; p = 0.023) and SBS or multiple resections (OR 3.47; 95% CI 1.24–9.70; p = 0.017) increased r...