Metal-Free Approach for Oxa-spirocyclohexadienones through [3 + 2]/[4 + 2] ipso-Cyclization of para-Quinone Methides with Halo Alcohols.

作者：Ramesh A Gaikwad, Amol T Savekar, S. Waghmode · 发表于：Journal of Organic Chemistry · 年份：2023 · DOI：10.1021/acs.joc.3c00784 · 被引用次数：11 · 研究领域：Medicine

A facile one-pot metal-free, base-mediated formal [3 + 2] and [4 + 2] dearomative ipso-cycloaddition of para-quinone methides (p-QMs) with halo alcohols has been designed for the efficient construction of 2-oxa-spirocyclohexadienones in excellent yield under mild reaction conditions. The commercial availability of the bases, reagents, and convenient reaction procedure makes it an attractive method for ipso-cyclization.