A panoramic view of cell population dynamics in mammalian aging

作者：Zehao Zhang, Chloe Schaefer, Weirong Jiang, Ziyu Lu, Jasper Lee, András Sziráki, A. Abdulraouf, Brittney Wick, Maximilian Haeussler, Zhuo-Yan Li, Gesmira Molla, R. Satija, Wei Zhou, Junyue Cao · 发表于：Science · 年份：2024 · DOI：10.1126/science.adn3949 · 被引用次数：54 · 研究领域：Medicine

To elucidate aging-associated cellular population dynamics, we present PanSci, a single-cell transcriptome atlas profiling >20 million cells from 623 mouse tissues across different life stages, sexes, and genotypes. This comprehensive dataset reveals >3000 different cellular states and >200 aging-associated cell populations. Our panoramic analysis uncovered organ-, lineage-, and sex-specific shifts in cellular dynamics during life-span progression. Moreover, we identify both systematic and organ-specific alterations in immune cell populations associated with aging. We further explored the regulatory roles of the immune system on aging and pinpointed specific age-related cell population expansions that are lymphocyte dependent. Our “cell-omics” strategy enhances comprehension of cellular aging and lays the groundwork for exploring the complex cellular regulatory networks in aging and aging-associated diseases. INTRODUCTION: As we age, certain cell types within the diverse cellular landscape of various organs undergo substantial changes. These alterations not only affect the overall function of the organism but also play a critical role in the development of age-related diseases. Cataloging these vulnerable cell types is essential for understanding the cellular basis of aging-related pathologies and for identifying potential interventions. However, the inherent heterogeneity and varying cell proportions within each organ make it challenging to identify rare but crucial aging-as...