Traditional herbal medicine Hyangsapyeongwi-san inhibits alcohol-induced gastric injury in mice by regulating NLRP3 inflammasome signaling.

作者：E. Huh, In Gyoung Ju, Seong Hye Kim, M. Kang, Seung-Min Lee, Huiwon Park, Minsik Choi, Suji Choi, Seong-Hoo Park, Hyangsook Lee, Y. Jang, M. S. Oh · 发表于：Journal of Ethnopharmacology · 年份：2026 · DOI：10.1016/j.jep.2026.121961 · 研究领域：Medicine

ETHNOPHARMACOLOGICAL RELEVANCE Hyangsapyeongwi-san (HPS), known as Xiangsha Pingwei San in Chinese medicine, is a classical herbal formula composed of ten medicinal herbs that has been traditionally used in traditional Korean medicine and East Asian medicine for centuries to treat gastrointestinal disorders associated with digestive impairment, including functional dyspepsia and gastritis. In traditional Korean medicine theory, these conditions correspond to "dampness-heat accumulation" and "qi stagnation" patterns affecting the spleen and stomach. HPS is formulated to "eliminate dampness, strengthen the spleen, and regulate qi circulation"-a traditional rationale for which the present study provides molecular evidence by demonstrating suppression of key inflammatory signaling pathways underlying gastric mucosal injury. AIM OF STUDY This study aimed to investigate the gastroprotective effects of HPS against acute gastric injury and to elucidate its underlying molecular mechanisms, with a focus on NLRP3 inflammasome activation. MATERIALS AND METHODS Male ICR mice were administered HPS (75 or 300 mg/kg) or ranitidine (40 mg/kg) orally once daily for 4 days prior to HCl/ethanol-induced gastric injury. Gastric damage, NLRP3 inflammasome components, inflammatory cytokines, signaling pathways, and apoptosis markers were assessed. Anti-inflammatory effects were further evaluated in TNF-α-stimulated MKN45 gastric epithelial cells. RESULTS HPS dose-dependently reduced gastric da...