Mice with a specific deficiency of Pfkfb3 in myeloid cells are protected from hypoxia‐induced pulmonary hypertension

作者：Lina Wang, Xiaoyu Zhang, Yapeng Cao, Qian Ma, Xiao-Xiao Mao, Jie-An Xu, Qiu-Hua Yang, Yaqi Zhou, R. Lucas, D. Fulton, Yunchao Su, S. Barman, Mei Hong, Zhi-Ping Liu, Yuqing Huo · 发表于：British Journal of Pharmacology · 年份：2020 · DOI：10.1111/bph.15339 · 被引用次数：39 · 研究领域：Medicine、Chemistry

Macrophage infiltration into the lungs is a characteristic of pulmonary hypertension (PH). Glycolysis is the main metabolic pathway for macrophage activation. However, the effect of macrophage glycolysis on the development of PH remains unknown. We investigated the effect of 6‐phosphofructo‐2‐kinase/fructose‐2,6‐bisphosphatase 3 (PFKBF3), a critical enzyme of macrophage glycolysis, on PH development.