3D molecular models of whole HIV-1 virions generated with cellPACK

作者：G. Johnson, D. Goodsell, L. Autin, Stefano Forli, M. Sanner, A. Olson · 发表于：Faraday discussions · 年份：2014 · DOI：10.1039/c4fd00017j · 被引用次数：60 · 研究领域：Medicine

As knowledge of individual biological processes grows, it becomes increasingly useful to frame new findings within their larger biological contexts in order to generate new systems-scale hypotheses. This report highlights two major iterations of a whole virus model of HIV-1, generated with the cellPACK software. cellPACK integrates structural and systems biology data with packing algorithms to assemble comprehensive 3D models of cell-scale structures in molecular detail. This report describes the biological data, modeling parameters and cellPACK methods used to specify and construct editable models for HIV-1. Anticipating that cellPACK interfaces under development will enable researchers from diverse backgrounds to critique and improve the biological models, we discuss how cellPACK can be used as a framework to unify different types of data across all scales of biology.