Utilization of MeOH as a C1 Building Block in Tandem Three-Component Coupling Reaction.

作者：K. Chakrabarti, M. Maji, Dibyajyoti Panja, Bhaskar Paul, S. Shee, G. Das, S. Kundu · 发表于：Organic Letters · 年份：2017 · DOI：10.1021/acs.orglett.7b02105 · 被引用次数：64 · 研究领域：Medicine、Chemistry

Ru(II) catalyzed tandem synthesis of α-branched methylated ketones via multicomponent reactions following the hydrogen borrowing process is described. This nonphosphine-based air and moisture stable catalyst efficiently produced various methylated ketones using methanol as a methylating agent. This system was found to be highly effective in three-component coupling between methanol, primary alcohols, and methyl ketones. A proposed catalytic cycle for the α-methylation is supported by DFT calculations as well as kinetic experiments.