Anatomical Structures, Cell Types, and Biomarkers Tables Plus 3D Reference Organs in Support of a Human Reference Atlas

作者：K. Börner, S. Teichmann, Ellen M. Quardokus, J. Gee, Kristen M. Browne, David Osumi-Sutherland, B. Herr, Andreas Bueckle, Hrishikesh Paul, M. Haniffa, Laura Jardine, Amy Bernard, Song-Lin Ding, Jeremy A. Miller, Shin Lin, M. Halushka, Avinash Boppana, T. Longacre, J. Hickey, Yiing Lin, M. T. Valerius, Y. He, Gloria S. Pryhuber, Xin Sun, Marda L. Jorgensen, Andrea J. Radtke, C. Wasserfall, F. Ginty, J. Ho, J. Sunshine, R. Beuschel, Maigan A. Brusko, Sujin Lee, R. Malhotra, Sanjay Jain, G. Weber · 发表于：Nature Cell Biology · 年份：2021 · DOI：10.1038/s41556-021-00788-6 · 被引用次数：93 · 研究领域：Medicine

The Human Reference Atlas (HRA) aims to map all of the cells of the human body to advance biomedical research and clinical practice. This Perspective presents collaborative work by members of 16 international consortia on two essential and interlinked parts of the HRA: (1) three-dimensional representations of anatomy that are linked to (2) tables that name and interlink major anatomical structures, cell types, plus biomarkers (ASCT+B). We discuss four examples that demonstrate the practical utility of the HRA. In this Perspective, Börner et al. discuss initiatives by 16 consortia to construct a Human Reference Atlas (HRA) comprising reference organs linked to tables that name major anatomical structures, cell types, plus biomarkers (ASCT+B) and present examples of HRA usage.