The Effects of COgNitive Training in Community-dwelling Older Adults at High Risk for demENTia (CONTENT): study protocol of two double-blind, randomized, placebo-controlled trials

作者：Y. Pan, M. Ji, J. Liang, J. Ma, W. Zhang, Y. Liu, Y. Dai, D. Gao, Y. Zhang, W. Xie, F. Zheng · 发表于：medRxiv · 年份：2025 · DOI：10.1101/2025.06.27.25330394 · 研究领域：Medicine

ABSTRACT Introduction Dementia contributes to the disease burden worldwide, and people with hypertension or type 2 diabetes are associated with an elevated risk of developing dementia. It is essential to prevent or delay cognitive decline in people at high risk within the community. Our trials aim to evaluate the effects of adaptive cognitive training on community-dwelling older adults with hypertension or type 2 diabetes but no dementia. Method and analysis Two multicenter, double-blind, randomized, placebo-controlled trials, named COgNitive Training in community-dwelling older adults at high risk for demENTia and with Hypertension (CONTENT-Hypertension) and COgNitive Training in community-dwelling older adults at high risk for demENTia and with Diabetes (CONTENT-Diabetes), will be conducted to investigate the effects of adaptive cognitive training on participants aged 60 years or above who have been diagnosed with hypertension or type 2 diabetes but no dementia. Each trial will enroll 120 participants. Participants will be recruited from local community in Shijingshan and Haidian District, Beijing, and allocated to either the intervention or control group using a 1:1 ratio. The intervention group will engage in 12 weeks of adaptive cognitive training, while the control group will receive 12 weeks of placebo cognitive training. A 24-week follow-up assessment will be conducted for all participants to evaluate the persistency of the effects. The primary outcome is the 12-week ...