Non-coding mutations drive persistence of a founder pre-leukemic clone which initiates late relapse in T-ALL.

作者：D. O'connor, J. Espejo Valle-Inclán, Lucia Conde, Gianna Bloye, Sunniyat Rahman, Joana R Costa, J. Bartram, S. Adams, G. Wright, Hillary Elrick, Kerry Wall, S. Dyer, Christopher Howell, Galina Jigoulina, Javier Herrero, I. Cortés-Ciriano, A. Moorman, Marc R. Mansour · 发表于：Blood · 年份：2024 · DOI：10.1182/blood.2023021906 · 被引用次数：5 · 研究领域：Medicine

T-ALL relapse usually occurs early but can occur much later, which has been suggested to represent a de novo leukemia. However, we conclusively demonstrate late relapse can evolve from a pre-leukemic subclone harbouring a non-coding mutation that evades initial chemotherapy.