The role of Tau, amyloid-β and neuroinflammation in the association between cognition and white matter hyperintensities in a southeast Asian cohort

作者：G. K. Sandhu, A. Vipin, Jacklyn Leonardo, F. Zailan, P. Tanoto, Faith Phemie Hui En Lee, Xin Ying Sim, S. Ghildiyal, Y. Leow, S. Y. Liew, G. Bhalla, Rasyiqah binte Shaik Mohamed Salim, Bocheng Qiu, N. Kandiah · 发表于：The journal of prevention of Alzheimer's disease · 年份：2025 · DOI：10.1016/j.tjpad.2025.100300 · 被引用次数：2 · 研究领域：Medicine

Structured Abstract Background Elevated Glial Fibrillary Acidic Protein (GFAP) is associated with increased Phosphorylated Tau 181 (pTau181) induced neurodegeneration in Alzheimer’s Disease. Objective However, the role of GFAP and pTau181 in vascular/mixed dementias requires elucidation within the Southeast Asian context, where their burden is considerable. Design Population based cross-sectional study. Setting Biomarkers and Cognition Study, Singapore (BIOCIS). Participants Baseline data from n = 583 (40.3 % male), non-demented but at risk, Southeast Asian community participants, were included in this analysis. All participants displayed cognitive symptoms on the Subjective Memory Complaints Questionnaire, although they may or may not have objective cognitive deficits and did not meet the criteria for dementia as per the DSM – 5. Methods Neuropsychological assessments for executive function evaluation, volumetric White Matter Hyperintensities (WMH) measurement and plasma biomarker expression, were determined in non-demented but at risk, Southeast Asian research participants. Partial correlation analysis demonstrated variable associations. Simple moderation analysis revealed the ability for plasma biomarkers to influence the relationship between executive function and WMH. Results WMH burden positively correlated to Neurofilament-Light (NfL) and pTau181. Executive function and processing speed negatively correlated to WMH burden. GFAP positively correlated to pTau181 and nega...