Associations of cardiovascular health assessed by life’s crucial 9 with incident cardiovascular disease and dementia: A prospective cohort study

作者：Yiwen Dai, Yuling Liu, Yang Pan, Jingya Ma, Jie Liang, Wenya Zhang, Xuyang Diao, Menghan Zhu, Xinqing Yang, Da-yong Gao, Yanyu Zhang, M. Ji, Yichi Zhang, W. Xie, F. Zheng · 发表于：The journal of prevention of Alzheimer's disease · 年份：2025 · DOI：10.1016/j.tjpad.2025.100273 · 被引用次数：7 · 研究领域：Medicine

Background The associations of the renewed cardiovascular health (CVH) assessed by Life’s Crucial 9 (LC9), which consisted of Life’s Essential 8 (LE8) and psychological health, with incident cardiovascular disease (CVD) and dementia remained unexplored. Objectives This study aims to investigate the associations and determine whether LC9 has a higher discrimination ability than LE8 in predicting incident CVD and dementia. Design, setting, and participants This study was a prospective population-based cohort study using data from the UK Biobank. Measurements LC9 was assessed as American Heart Association recommended. Incident CVD and dementia were based on self-reported data, hospital inpatient records, and death register records. Results Of 289,649 included participants, 137,480 (47.5 %) were male, and the mean age was 56.6 ± 8.1 years. Compared with participants having low LC9, those having moderate or high LC9 had lower risks of incident CVD (moderate: 0.46 [0.43–0.48]; high: 0.25 [0.23–0.27]; p for trend <0.001) and dementia (moderate: 0.57 [0.50–0.64]; high: 0.45 [0.39–0.52]; p for trend <0.001) after multivariate adjustment. Both the LE8 and LC9 achieved good discriminative performance for incident CVD (LE8 Harrell C-statistic= 0.7138 vs. LC9 Harrell C-statistic=0.7144, p = 0.136); the net reclassification improvement was estimated at 0.07 % (p = 0.749), and integrated discrimination improvement was estimated at 0.009 (p < 0.001). The results for dementia showed similar p...