Glutathione Dynamics in Subcellular Compartments and Implications for Drug Development

作者：Han-Qing Lin, Ling-Fei Wang, Xiqian Jiang, Jin Wang · 发表于：Current Opinion in Chemical Biology · 年份：2024 · DOI：10.1016/j.cbpa.2024.102505 · 被引用次数：28 · 研究领域：Medicine

Glutathione (GSH) is a pivotal tripeptide antioxidant essential for maintaining cellular redox homeostasis and regulating diverse cellular processes. Subcellular compartmentalization of GSH underscores its multifaceted roles across various organelles including the cytosol, mitochondria, endoplasmic reticulum, and nucleus, each exhibiting distinct regulatory mechanisms. Perturbations in GSH dynamics contribute to pathophysiological conditions, emphasizing the clinical significance of understanding its intricate regulation. This review consolidates current knowledge on subcellular GSH dynamics, highlighting its implications in drug development, particularly in covalent drug design and antitumor strategies targeting intracellular GSH levels. Challenges and future directions in deciphering subcellular GSH dynamics are discussed, advocating for innovative methodologies to advance our comprehension and facilitate the development of precise therapeutic interventions based on GSH modulation.