Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis.

作者：S. Melo, H. Sugimoto, Joyce T. O’Connell, Noritoshi Kato, A. Villanueva, A. Vidal, Le Qiu, E. Vitkin, L. Perelman, C. A. Melo, A. Lucci, C. Ivan, G. Calin, R. Kalluri · 发表于：Cancer Cell · 年份：2025 · DOI：10.1016/j.ccell.2025.07.022 · 被引用次数：633 · 研究领域：Medicine

Sonia A. Melo,1,2 Hikaru Sugimoto,1,2 Joyce T. O’Connell,2 Noritoshi Kato,2 Alberto Villanueva,3 August Vidal,4 Le Qiu,5 Edward Vitkin,5 Lev T. Perelman,5 Carlos A. Melo,6,7 Anthony Lucci,8 Cristina Ivan,9 George A. Calin,10 and Raghu Kalluri1,2,* 1Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA 2Division of Matrix Biology, Department of Medicine, Beth Israel DeaconessMedical Center and HarvardMedical School, Boston, MA 02215, USA 3Translational Research Laboratory, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, Barcelona 08908, Spain 4Department of Pathology, Hospital Universitari de Bellvitge, Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, Barcelona 08908, Spain 5Department of Obstetrics, Gynecology, and Reproductive Biology, and Department of Medicine, Center for Advanced Biomedical Imaging and Photonics, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA 6Division of Gene Regulation, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands 7Doctoral Programme in Biomedicine and Experimental Biology, Centre for Neuroscience and Cell Biology, 3004-517 Coimbra, Portugal 8Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA 9Center for RNA Interference and Non-coding RNAs, University of Texas MD Anderson Cancer Center, ...