Dicarbofunctionalization of [1.1.1]Propellane: One-Step Multicomponent Approach to BCP-Aryl Derivatives.

作者：Yumei Huo, Liang Liu · 发表于：Organic Letters · 年份：2026 · DOI：10.1021/acs.orglett.6c01849 · 被引用次数：1 · 研究领域：Medicine

Aryl-substituted bicyclo[1.1.1]pentanes (BCPs) are valuable scaffolds in drug discovery. However, their synthesis typically requires multistep sequences via prefunctionalized [1.1.1]pentane. Herein, we report a metal-free, visible-light-driven three-component dicarbofunctionalization of [1.1.1]propellane via an electron donor-acceptor (EDA) complex. This method provides direct and diverse access to 1,3-disubstituted BCPs under mild conditions with operational simplicity and green chemistry, featuring good functional group tolerance from readily available starting materials.