Cuproptosis enters the cancer-immunity circuit

作者：Gao Y, Xing N · 发表于：Cell · 年份：2026 · DOI：10.1016/j.cell.2026.07.042 · 研究领域：Cuproptosis、Neoplasms、Humans、Animals、Dendritic Cells、CD8-Positive T-Lymphocytes

In this issue of Cell, Lei et al. reveal a reciprocal circuit in which cuproptotic tumor cells promote dendritic cell activation and CD8+ T cell priming, whereas T cell-derived IFN-γ sensitizes tumor cells to FDX1-dependent cuproptosis. This self-reinforcing interaction provides a mechanistic rationale for combining cuproptosis induction with PD-L1 blockade to overcome immunotherapy resistance.