Clinical, Molecular, and Immunological Characteristics of Scrub Typhus in Nepal

作者：Adhikari A, Münch C, En-Nosse N, Rayamajhee B, Karki G, Gc B, Oli P, Fromm L, Schwarz J, Sapre S, Mehl J, Aryal S, Tappe D, Keller C · 发表于：Open forum infectious diseases · 年份：2026 · DOI：10.1093/ofid/ofag390 · 被引用次数：22

In a serologically diagnosed Nepalese scrub typhus cohort (n = 77), gastrointestinal symptoms were common. We assessed Orientia tsutsugamushi DNA in serum and performed TSA56 genotyping. Orientia DNA was detected in 10 of 77 samples (12%). TSA56 sequencing identified 4 genotypes. Polymerase chain reaction positivity was associated with diarrhea, groin lymphadenopathy, and stronger Th1-type cytokine responses.