Evaluating Artificial Intelligence Translation Tools for Language Equivalence of Oncology-Informed Consent Forms From English to Spanish

作者：Khanna S, Woo S, Susanibar-Adaniya SP, Weissman GE, Blair ML, Bruno XJ, Guerra CE · 发表于：JCO oncology practice · 年份：2026 · DOI：10.1200/OP-26-00317

PURPOSE: Approximately 8% of the US population speaks primary languages other than English. Limited English proficiency (LEP) contributes to under-representation of Hispanic patients in oncology clinical trials. Although certified translation services exist, they are time-consuming and costly. Artificial intelligence (AI)-generated translations of informed consent forms (ICFs) could provide low-cost alternatives, but data on accuracy and safety remain limited. We evaluated language equivalence of English-to-Spanish translations for three oncology clinical trial ICFs using two general-purpose AI translation tools (DeepL Pro and ChatGPT-4o) and a medically trained AI translation tool (Med_English2Spanish) compared with certified translations. METHODS: Translational equivalence was assessed using a five-point Likert scale on five domains: Semantic, Idiomatic, Experiential, Conceptual, and Safety. Two native Spanish-speaking bilingual board-certified physicians independently scored each translation. Weighted Cohen's kappa determined inter-rater reliability, and the two-sample t-test compared AI-generated and certified translations. RESULTS: Weighted Cohen's kappa (0.95, 95% CI 0.85 to 0.97) exhibited high inter-rater agreement. Certified translations exhibited the highest equivalence (mean = 4.99, SD = 0.02). ChatGPT-4o similarly demonstrated high equivalence (mean = 4.89, SD = 0.17). DeepL Pro scored well (mean = 4.43, SD = 0.07) but lower than certified translation (P < 0.001...