When lactate speaks: Rewiring astrocyte-neuron metabolism in Alzheimer's disease

作者：Furtado J, Schneeberger M · 发表于：Cell metabolism · 年份：2026 · DOI：10.1016/j.cmet.2026.05.007 · 研究领域：Astrocytes、Alzheimer Disease、Neurons、Lactic Acid、Humans、Animals、Glycolysis、Glucagon-Like Peptide-1 Receptor

Metabolic dysfunction is a defining but poorly understood feature of Alzheimer's disease. Du et al. show that a brain-penetrant GLP-1 receptor agonist rewires astrocyte-neuron metabolic coupling through lactate-driven histone lactylation, linking astrocytic glycolysis to neuronal lipid homeostasis and positioning metabolite signaling as a therapeutic axis in neurodegeneration.