Mapping the evolution and impact of microfluidic technology research on cancer diagnosis: A comprehensive bibliometric analysis from 2015 to 2024

作者：Su X, Pu J, Liao J, Li J, Huang J, Wu Z · 发表于：Medicine · 年份：2026 · DOI：10.1097/md.0000000000049910 · 被引用次数：48 · 研究领域：Neoplasms、Bibliometrics、Microfluidics、Microfluidic Analytical Techniques、Humans

BACKGROUND: To explore the research trends of microfluidic technology for cancer diagnosis from 2015 to 2024 using bibliometric and visualization methods (not a Preferred Reporting Items for Systematic Reviews and Meta-Analyses-compliant systematic review), and provide references for subsequent scientific research. METHODS: Relevant literatures were retrieved from the Web of Science Core Collection, and analyzed using tools such as Origin 2018, R software, VOSviewer, and CiteSpace. The cooperation network, co - citation network, and keyword co - occurrence network was constructed. RESULTS: A total of 897 literatures were included. The number of literatures first increased, then decreased, and then increased again, reaching a peak in 2023. China had the highest literature output (358 articles), but the international co - authorship rate was low (19%). Biosensors & Bioelectronics had high publication and citation numbers. The research hotspots were the isolation and detection of circulating tumor cells (with a focus on breast cancer, colorectal cancer, and lung cancer, accounting for 36%) and microfluidic analysis of exosomes (accounting for 24%). Keyword clustering involved microfluidic device materials, tumor cell detection, exosome applications, and cancer mechanism research. The research direction shifted from broad-based technology to precise applications for specific cancers and samples. CONCLUSION: This study clarified the research status and hotspots in this field. M...