Global research landscape and trends of metabolomics in diabetic kidney disease: focus on immunometabolic interactions

作者：Li Y, Li C, Duan J, Yang Q, Zhang J, Yu D, Chen Y, Ni J, Lin X, Cai X · 发表于：Frontiers in clinical diabetes and healthcare · 年份：2026 · DOI：10.3389/fcdhc.2026.1791774 · 研究领域：citespace、diabetic kidney disease、inflammation、metabolomics、pubmed、web of science

INTRODUCTION: Diabetic kidney disease (DKD), a devastating microvascular complication of diabetes mellitus, arises from intricate crosstalk between metabolic disorders and immune dysregulation. Metabolomics has emerged as a powerful tool to unravel the immunometabolic mechanisms underlying DKD, facilitating early disease diagnosis, mechanistic pathway interpretation, and therapeutic biomarker discovery. This study aimed to systematically delineate the global research landscape and evolutionary trends of DKD metabolomics, with a key emphasis on immunometabolic interactions. METHODS: Relevant publications on DKD metabolomics published between 2015 and 2025 were comprehensively retrieved from the Web of Science Core Collection and PubMed databases. Multiple bibliometric and visualisation tools, including CiteSpace and the online bibliometric platform (https://bibliometric.com/), were utilised for data processing, visual mapping, and integrated quantitative and qualitative analysis. RESULTS: A total of 1,410 eligible articles were included in the final analysis, among which 1,110 were sourced from the Web of Science and 299 from PubMed, demonstrating a sustained annual growth in publication volume. China contributed the largest number of publications (663 articles), followed by the United States (207 articles). The University of Michigan and Shandong University were the most productive research institutions. Li Ping and Sharma Kumar were identified as the leading productive and...