Defect-Engineered Porous C(3)N(4)/CoFe-LDH Quantum Dot Heterostructures for Synergistic Photocatalytic-Nanozyme Antibacterial Therapy

作者：Wang L, An M, Wang Y, Zhong W, Cai L, Zhang J, Li J, Xiao J, Zhang G, Ding L, Tian G, Wang A, Yu X · 发表于：Advanced healthcare materials · 年份：2026 · DOI：10.1002/adhm.71418 · 研究领域：antibacterial activity、multidrug‐resistant pathogens、nanozyme、photocatalysis、skin anti‐infective therapy

Bacterial infections and the spread of multidrug-resistant pathogens pose a growing threat to public health as conventional antibiotics lose efficacy, necessitating efficient non-antibiotic antibacterial strategies. Although ROS-based photocatalysis and nanozyme catalysis are promising, single-component systems are often limited by charge-carrier recombination, low ROS generation efficiency, and slow reaction kinetics. Herein, we report a porous C3N4@oxygen-vacancy-rich CoFe-LDH quantum-dot (p-CN@CF-O) composite heterostructure, in which ultrasmall CoFe-LDH quantum dots are uniformly anchored onto the surface of porous C3N4 (p-CN), forming robust and intimate heterointerfaces. The defect-rich p-CN framework facilitates charge transport and reactant adsorption, while oxygen vacancies in the CoFe-LDH quantum dots markedly enhance peroxidase-like activity and promote interfacial charge separation. The cooperative effect of multilevel defects significantly boosts ROS generation, enabling highly efficient antibacterial activity under mild conditions. Moreover, the composite serves as a micro-scaffold that supports epidermal cell proliferation and migration. In a skin infection model in vivo, this material effectively eradicates bacteria, suppresses biofilm formation, and accelerates wound healing, demonstrating outstanding potential for skin anti-infective therapy. This work not only establishes an efficient photocatalysis-nanozyme synergistic antibacterial strategy, but also prov...