Multi-omics integration deciphers arsenic-induced multi-organ toxicity and the novel ferroptosis axis

作者：Zhang X · 发表于：Toxicology reports · 年份：2026 · DOI：10.1016/j.toxrep.2026.102308 · 被引用次数：52 · 研究领域：Arsenic exposure、Ferroptosis、GPX4、Machine learning、Multi-omics integration、Organ-specific toxicity、Selenium metabolism disruption、Spatial omics

Chronic arsenic exposure threatens over 200 million people worldwide and induces multi-organ injury, yet the panoramic molecular reprogramming across organs remains incompletely understood, and traditional single-omics approaches fail to capture cross-level and cross-organ regulatory associations. This review systematically integrates evidence from global epidemiology to single-cell spatial omics, tracing the evolution of multi-omics technologies-from single-platform profiling to data fusion strategies such as coupled matrix factorization (CMF) and the DIABLO framework, two complementary multi-omics integration approaches-and to cutting-edge spatial transcriptomics. We highlight ferroptosis as a common mechanism in arsenic-induced multi-organ injury. At the molecular level, we propose a mechanistic model wherein arsenic (AsIII) disrupts selenium metabolism by inhibiting Sec-tRNASec synthesis, thereby impairing selenoprotein (especially GPX4) biosynthesis, a paradigm distinct from the traditional "ROS burst → lipid peroxidation" theory. Supporting evidence includes reduced 75Se incorporation into cellular RNA, genetic deletion of PRDX6 exacerbating ferroptosis, and rescue by selenium supplementation via Nrf2 activation. At the organ level, we compare toxicity features and propose that tissue-intrinsic ferroptosis thresholds-determined by iron content, PUFA-phospholipid composition, GSH reserves, GPX4 redundancy, and selenium availability-govern differential organ susceptibilit...