Associations between prevalent unhealthy lifestyles and the gut microbiota: a comprehensive multi-database bibliometric analysis of pathogenic mechanisms and clinical trajectories

作者：Zhou XJ, Chen JL, Hu CF, Li ZK, Zheng HB, Ding TN, Chen Y, Zhu Y, Li JN, Fu Q, Fu Y · 发表于：Frontiers in medicine · 年份：2026 · DOI：10.3389/fmed.2026.1834916 · 被引用次数：76 · 研究领域：bibliometric analysis、clinical translation、gastrointestinal microbiome、inflammation、metabolic dysfunction、obesity、unhealthy lifestyle

BACKGROUND: Unhealthy lifestyles are associated with gut microbiota dysbiosis through complex inflammatory and immune-related pathways. Despite extensive primary research, comprehensive big-data syntheses mapping this field remain limited. This study systematically analyzes the research landscape, related pathophysiological processes, and emerging trends in the field of lifestyle-microbiome interactions using a multi-database bibliometric framework. METHODS: A dual-database retrieval strategy utilized the Web of Science Core Collection (WoSCC) and PubMed. The analysis targeted five predominant unhealthy lifestyles: smoking, alcohol consumption, sleep disorders, sedentary behavior, and high-sugar diets. A primary dataset of 5,380 records published between January 1, 2001, and March 13, 2026, was extracted from WoSCC. A parallel clinical analysis incorporated 172 targeted studies from PubMed. Bibliometric analyses, encompassing publication trends, network topologies, citation bursts, keyword evolution, and clinical trajectories, were performed and visualized using Microsoft Excel 2024, VOSviewer, CiteSpace, SCImago, and R. RESULTS: Publication output exhibited exponential growth from 2001 to 2026. China and the United States emerged as the dominant academic contributors. Thematic analyses identified inflammation, oxidative stress, obesity, metabolic dysfunction, and microbiome-associated metabolomics as core pathophysiological nodes. The literature frequently describes these ...