Substantial early morbidity and incomplete left ventricular recovery in Takotsubo syndrome: A single-center cohort study

作者：Mansour M, Sanalla S, Semel A, Massalha E, Milwidsky A, Herscovici R, Chernomordik F, Matetzky S, Beigel R · 发表于：International journal of cardiology · 年份：2026 · DOI：10.1016/j.ijcard.2026.134579 · 研究领域：Takotsubo Cardiomyopathy、Recovery of Function、Ventricular Function, Left、Humans、Female、Retrospective Studies、Aged、Male、Cohort Studies、Middle Aged、Electrocardiography、Stroke Volume

AIMS: Takotsubo syndrome is an acute cardiac syndrome that mimics myocardial infarction. Despite its transient nature, substantial early morbidity may occur, while predictors of short-term recovery and adverse in-hospital outcomes remain incompletely characterized. METHODS: We performed a retrospective study of consecutive adults diagnosed with Takotsubo syndrome at a tertiary center between 2011 and 2024. Patients with pre-existing cardiomyopathy or heart failure with reduced ejection fraction were excluded. Clinical, electrocardiographic, echocardiographic, and laboratory data, as well as in-hospital outcomes, were analyzed. Early left ventricular recovery was defined as achieving an ejection fraction ≥50% at discharge. Associations with recovery and major in-hospital complications were evaluated using univariate and exploratory multivariable analyses. RESULTS: A total of 189 patients were included (median age 69 years; 99% women). ST-segment elevation was present in 32%, and QTc prolongation exceeding 20% from baseline occurred in 18%. Median ejection fraction improved from 35% (IQR 30-45%) on admission to 45% (IQR 35-60%) at discharge (p < 0.01). Moderate-to-severe mitral regurgitation declined from 5.8% to 1.6% by discharge. Early left ventricular recovery during hospitalization was observed in only 31% of patients. Shorter QT and PR intervals at discharge were associated with concurrent myocardial recovery. In-hospital arrhythmias occurred in 12%, vasopressor use in 2...