Macrophages in Psoriasis: From Functional Heterogeneity to Metabolic Reprogramming and Novel Therapeutics

作者：Liu Q, Wu Y, Tang J, Kuang Y · 发表于：Experimental dermatology · 年份：2026 · DOI：10.1111/exd.70275 · 研究领域：Psoriasis、Macrophages、Humans、Metabolic Reprogramming、Th17 Cells、Animals、Keratinocytes、Signal Transduction、Neutrophils、Fibroblasts、Sensory Receptor Cells

This review provides a comprehensive overview of macrophage heterogeneity, polarisation dynamics, metabolic reprogramming and multicellular interactions of macrophages in psoriasis. We discuss how single-cell technologies have revealed diverse macrophage subsets and explore the metabolic profile of macrophages in psoriasis. Furthermore, we examine the central role of macrophages in intercellular networks with keratinocytes, T helper 17 (Th17) cells, neutrophils, fibroblasts and sensory neurons. Additionally, we summarise the novel signal way of macrophages and tissue injury by macrophages. Finally, we summarise emerging therapeutic strategies-including metabolic modulators, signalling pathway inhibitors, advanced delivery systems and cell-based therapies. By integrating recent insights from single-cell omics, spatial transcriptomics and metabolic studies, this review underscores the potential of macrophage-focused interventions for psoriasis treatment.