[Predictive value of the modified Nutrition Risk in Critically Ill Score for intensive care unit mortality risk in septic patients]

作者：Xie M, Huang D, Huang L, Qin Y, Feng B, Cai Q, Li L, Lang Q · 发表于：Zhonghua wei zhong bing ji jiu yi xue · 年份：2026 · DOI：10.3760/cma.j.cn121430-20250716-00390 · 研究领域：Sepsis、Nutrition Assessment、Humans、Intensive Care Units、Critical Illness、Prospective Studies、Female、Male、Middle Aged、Prognosis、Aged、Hospital Mortality

OBJECTIVE: To explore the predictive value of the first modified Nutrition Risk in the Critically Ill Score (mNUTRIC) assessed within 24 hours of admission to the intensive care unit (ICU) for the risk of ICU mortality in patients with sepsis. METHODS: A single-center prospective cohort study was conducted, enrolling septic patients admitted to the department of critical care medicine, the First Affiliated Hospital of Guangxi Medical University, from November 2024 to June 2025. Basic patient information, past medical history, complications, critical care-related scores and initial laboratory parameters obtained within 24 hours of ICU admission, as well as the duration of continuous renal replacement therapy (CRRT), mechanical ventilation and physical restraint during ICU stay were collected. The mNUTRIC score was calculated for each patient. Patients were followed up to record ICU mortality and length of ICU stay. According to the mNUTRIC score, patients were divided into four groups: Q1 group (mNUTRIC score<4 points), Q2 group (4 points≤mNUTRIC score<5 points), Q3 group (5 points≤mNUTRIC score<6 points) and Q4 group (mNUTRIC score≥6 points). The above-mentioned indicators were compared among the four groups. Multivariate Cox regression analysis was used to evaluate the association between the first mNUTRIC score within 24 hours of ICU admission and ICU mortality in septic patients. Restricted cubic spline (RCS) analysis was performed to test the dose-response relationship b...