The diagnostic yield of a structured comorbidity workup in a real-life outpatient population with obstructive sleep apnea: a cross-sectional study

作者：Zhang X, Tang H, Han T, Li Y, Su L · 发表于：Annals of medicine · 年份：2026 · DOI：10.1080/07853890.2026.2622175 · 被引用次数：40 · 研究领域：Sleep Apnea, Obstructive、Humans、Cross-Sectional Studies、Male、Female、Comorbidity、Middle Aged、Aged、Hypertension、Diabetes Mellitus, Type 2、Dyslipidemias、Metabolic Syndrome

BACKGROUND: Obstructive sleep apnea (OSA) is associated with multiple systemic complications. However, evidence-based recommendations for comorbidity screening remain sparse. This study aimed to evaluate whether a structured comorbidity workup could yield clinically meaningful diagnostic gains in OSA patients. METHODS: In this single-center cross-sectional observational study, patients diagnosed with OSA underwent a standardized comorbidity assessment including laboratory tests, electrocardiogram, echocardiography, abdominal ultrasound, ambulatory blood pressure monitoring, spirometry, and validated questionnaires. RESULTS: A total of 1904 OSA patients were included. Before evaluation, patients had a median of two [IQR 1-2] known comorbidities. The structured workup identified 3,200 newly diagnosed conditions, with a median of two [IQR 1-2] new diagnoses per patient. The most frequent comorbidities were dyslipidaemia (55%), type 2 diabetes mellitus (32%), metabolic syndrome (31%), hypertension (30%), non-alcoholic fatty liver disease(29%), hyperuricemia (29%), significant coronary artery disease (15%), arrhythmia (16%), heart failure with preserved ejection fraction (13%), obesity hypoventilation syndrome (19%), chronic obstructive pulmonary disease (8%) , asthma (12%), gastro-oesophageal reflux disease (17%), anxiety or depression (17%), and thyroid dysfunction (6%). Older age, male sex and lower mean oxygen saturation were independently associated with a higher comorbidit...