Research hotspots and trends of hyperbaric oxygen therapy in stroke: bibliometrics and visual analysis

作者：Lu L, Zhao L, Xie Y, Wang L, Ji Y, Luo X, Zhang C · 发表于：Medical gas research · 年份：2026 · DOI：10.4103/mgr.medgasres-d-25-00063 · 研究领域：bibliometrics、cerebral hemorrhage、cerebral infarction、hyperbaric oxygen、hyperbaric oxygen preconditioning、hyperbaric oxygen therapy、hyperbaric oxygenation、ischemic stroke、stroke、visual analysis

As a non-invasive and drug-free treatment method, hyperbaric oxygen therapy has been applied in cerebrovascular accidents to improve cerebral hypoxia, reduce ischemia-reperfusion injury following stroke and promote neural repair. However, its clinical efficacy remains controversial. This work aims to analyze the progress of research on the role of hyperbaric oxygen in stroke through bibliometric methods and takes relevant literature from the Web of Science core database from 2007 to December 31, 2024. The results showed that from 2007 to the present, the annual number of English publications in this field has shown a fluctuating but gradual upward trend, with the peak in publication volume occurring in 2015. China is in a leading position in this field, but there is still a lack of international cooperation and high-impact journal articles from Chinese institutions and researchers. The top five keywords were "hyperbaric oxygen" (84 occurrences), "stroke" (46 occurrences), "hyperbaric oxygen therapy" (45 occurrences), "focal cerebral ischemia" (27 occurrences), and "cerebral ischemia" (26 occurrences). A total of 13 major research areas were identified, including #0 stem cells, #1 hyperbaric oxygen, #2 perfusion, #3 EPR oximetry, #4 tPA, #5 rehabilitation, #6 acute stroke, #7 TBI, #8 stroke medicine, #9 hyperbaric oxygen preconditioning, #10 preconditioning, #11 ischemia-reperfusion injury, and #12 hyperbaric. At present, there are relatively few clinical trials registered on ...