Association between appendicular skeletal muscle index and bone turnover markers and bone mineral density in postmenopausal osteoporotic women

作者：Chen YC, Chen FP, Chang CW · 发表于：Archives of osteoporosis · 年份：2025 · DOI：10.1007/s11657-025-01648-8 · 研究领域：Bone Density、Osteoporosis, Postmenopausal、Muscle, Skeletal、Bone Remodeling、Humans、Female、Cross-Sectional Studies、Middle Aged、Aged、Biomarkers、Peptide Fragments、Procollagen

UNLABELLED: This was a cross-section study of postmenopausal women with osteoporosis/fractures. In multivariate analysis, P1NP was independently and negatively correlated with appendicular skeletal muscle index (ASMI). ASMI was positively correlated with body mass index and bone mineral density and negatively associated with smoking. ASMI assessment is crucial for postmenopausal osteoporotic women. PURPOSE: To evaluate the relationship between appendicular skeletal muscle index (ASMI) and bone turnover markers and bone mineral density (BMD) in postmenopausal women with osteoporosis. METHODS: This cross-sectional study recruited 313 postmenopausal osteoporosis/fracture women from the Osteoporosis Prevention and Treatment Center of Keeling Chang Gung Memorial Hospital. Assessment included anthropometric data, medical history, lifestyle factors, 25-hydroxyvitamin D, parathyroid hormone, procollagen type 1 amino-terminal propeptide (P1NP), carboxy-terminal collagen crosslinks (CTX), lateral thoracolumbar spine x-rays, BMD, and ASMI. RESULTS: The prevalence of low ASMI in postmenopausal women with osteoporosis was 30.0%. The mean value of P1NP (66.2 ± 38.7 ng/mL) and CTX (0.45 ± 0.25 ng/mL) were both higher than the cutoff values proposed as treatment targets. Univariate linear regression analysis showed that ASMI was positively correlated with age, body mass index (BMI), and total hip, femoral neck, and lumbar spine BMD. Smoking and P1NP levels were negatively associated with ...