Metabolic-Nutritional Associations with Depression in Elderly Chronic Kidney Disease Patients: Hemodialysis Versus Non-Dialysis Populations

作者：Ozdemir S, Cakici AE, Bilir İ · 发表于：Metabolites · 年份：2025 · DOI：10.3390/metabo15110710 · 被引用次数：56

Background/Objectives: This study aimed to evaluate the interrelationship between depression and nutritional-metabolic status in geriatric patients with chronic kidney disease (CKD), and to identify the contributing clinical and sociodemographic factors, with a particular focus on differences between patients receiving and not receiving hemodialysis treatment. Methods: This cross-sectional descriptive study was conducted between September 2023 and September 2024 in Gaziantep, Turkey. A total of 152 CKD patients aged 65 years and older were included, with 78 receiving hemodialysis and 74 managed without dialysis. Nutritional status was assessed using the Mini Nutritional Assessment-Short Form (MNA-SF), and depression levels were measured using the Geriatric Depression Scale-Short Form (GDS-SF). Laboratory parameters such as hemoglobin and serum albumin were also recorded. Results: A total of 152 geriatric CKD patients were included, with 78 (51.3%) undergoing hemodialysis and 74 (48.7%) not receiving dialysis. The non-dialysis group had significantly higher age (77.07 ± 8.61 vs. 70.13 ± 7.76 years, p = 0.001) and BMI (28.44 ± 4.70 vs. 25.18 ± 4.75, p = 0.001). Serum albumin levels were lower in non-dialysis patients (2.53 ± 0.67 vs. 3.50 ± 0.465 g/dL, p < 0.001), while hemoglobin (12.44 ± 2.03 vs. 11.16 ± 1.92 g/dL, p = 0.001) and ALT levels (17.16 ± 13.06 vs. 8.53 ± 4.31 U/L, p = 0.001) were higher. Malnutrition was more frequent among non-dialysis patients (20.3% vs. 9.0%, p...