Inflammatory markers predict MIA syndrome progression and cardiovascular disease outcomes in maintenance dialysis patients

作者：Chen S, Yang P, Lv H, Wang W, Zhang Q, Pan H, Yu S · 发表于：BMC nephrology · 年份：2025 · DOI：10.1186/s12882-025-04578-2 · 被引用次数：43 · 研究领域：Renal Dialysis、Inflammation、Cardiovascular Diseases、Malnutrition、Atherosclerosis、Humans、Male、Female、Biomarkers、Retrospective Studies、Disease Progression、C-Reactive Protein

OBJECTIVE: To investigate associations between inflammatory markers and malnutrition-inflammation-atherosclerosis (MIA) syndrome in dialysis patients and evaluate their predictive value for cardiovascular events. METHODS: This retrospective cohort study enrolled 197 maintenance dialysis patients (2017–2022). Inflammatory markers (CRP, IL-6, TNF-α), nutritional parameters, and atherosclerosis indicators were collected at baseline, 6, 12, and 24 months. Multivariate regression and Cox models assessed associations with MIA syndrome and cardiovascular outcomes. RESULTS: Elevated inflammatory markers were significantly associated with MIA syndrome severity and cardiovascular events (P < 0.001). High-inflammation patients had higher MIA scores (8.7 ± 2.1 vs. 6.4 ± 1.9, P < 0.001). CRP correlated negatively with albumin (r=-0.41) and positively with carotid intima-media thickness (r = 0.36, both P < 0.001). Hemodialysis patients showed higher CRP levels (8.2 ± 4.4 vs. 6.1 ± 3.7 mg/L, P = 0.011) and cardiovascular event rates (46.3% vs. 29.2%, P = 0.027) than peritoneal dialysis patients. Inflammatory changes correlated with MIA progression (r = 0.37, P < 0.001). After adjustment, CRP (HR = 1.17, 95% CI: 1.08–1.26), IL-6 (HR = 1.12, 95% CI: 1.04–1.20), and TNF-α (HR = 1.14, 95% CI: 1.05–1.23) independently predicted cardiovascular events. CONCLUSION: Inflammatory markers independently associate with MIA syndrome and cardiovascular events in dialysis patients. Hemodialysis patients de...