Optimizing dosimetry in Y-90 microsphere radioembolization: GPU-accelerated Monte Carlo simulation versus conventional methods for high-volume setting

作者：Hongming L, Ziwei L, Ziyi H, Shuiyin Q, Ankang H, ShuChang Y, Zhen W, Hui Z, Junli L, Rui Q · 发表于：EJNMMI physics · 年份：2025 · DOI：10.1186/s40658-025-00794-9 · 研究领域：90Y、Dosimetry、Fast Monte Carlo simulation、GPU、Nuclear medicine

BACKGROUND: Yttrium-90 (90Y) microsphere radioembolization has shown unique advantages in treating both primary and metastatic liver cancer and was introduced into China in 2022. Despite the development of various dosimetric models-ranging from empirical to voxel-based approaches-practical implementation remains challenging. With over 370,000 new liver cancer cases annually and limited access to certified 90Y treatment centers, Chinese interventional oncology departments face increasing pressure to balance dosimetric accuracy with clinical efficiency. This study aims to develop a GPU-based fast Monte Carlo project for accurate voxel-level dose calculation and to evaluate its performance alongside existing dosimetric strategies, with the goal of supporting optimized clinical workflows in high-volume settings. METHODS: A fast Monte Carlo simulation algorithm was developed using Graphics Processing Unit (GPU) acceleration and applied retrospectively to eight patients diagnosed with hepatocellular carcinoma or metastatic colorectal cancer. The dosimetric performance of the GPU-based approach was compared against direct Monte Carlo (MC) simulations, the Medical Internal Radiation Dose (MIRD) formalism, the Voxel S-value (VSV) method, and the Local Energy Deposition (LED) model. Voxel- and organ-level dose accuracy were quantified using metrics such as Mean Absolute Relative Error (MARE), Relative Standard Deviation (RSD), and D95 in dose volume histogram. Statistical comparisons ...